More wine and fewer calories prolong life

Reducing calorie consumption and wine consumption leads to longevity, according to a Spanish study.

According to a study conducted by Biochemical group for aging at the University of SevilleIf we reduce calorie consumption by 30 percent and moderate wine consumption, we can extend our longevity.

This group on the biochemistry of aging at the University of Seville is exploring new mechanisms for controlling human aging, focusing mainly on reducing calories and compensating for them with foods containing antioxidants, as is the case with red wine.

Currently and according to this study, the age limit for a person is 122 years, while life expectancy in Spain is 83 years for women and 77 for men.

As a result, the group’s first goal is to know what’s going on in the cells to transfer life expectancy from 77 years to 122 years, which people are able to reach. In any case, scientific advances allow life expectancy to increase by more than ten hours each day.

There are currently more than 300 theories in the scientific world about controlling human aging. Some, as pointed out by Universidad Hispalense professor and project leader Antonio Ayala, almost all of these theories are outdated or overlap with others more innovative.

The group on the biochemistry of aging is based on the theory of free radicals, which ensures that the most common life processes of the human being, such as respiration, for example, cause damage to our body, which increases with age.

The liver, through detoxification processes, also releases oxidants that affect us. Therefore, researchers want to know what is happening and what could be the mechanisms of intervention to reduce the effects that harm us, and to strengthen the defenses to reduce, as Ayala himself assures, that our metabolism has side effects. .

These damage, according to the group’s study, can be minimized by a 30% reduction in daily calorie intake, as this would enhance protein synthesis, which reduces endogenous damage to vital processes in addition to fat reduction.

Also, this calorie restriction activates sirtuin, which is a protein that thickens DNA, making it more resistant to all the harmful mutagens we are exposed to on a daily basis.

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Red wine also intervenes at this time, as it contains resveratrol, a compound that determines the function of sirtuin. Therefore, thanks to wine, the diet does not need to be so limited.

In the laboratories, the group from the Faculty of Pharmacy simulates small in vitro lesions in mice that occur endogenously.

When these lesions occur, the proteins bind or communicate with sirtuin, thanks to molecular language. This is another goal of the researchers. By decoding the molecular language, we could improve it to allow cells to respond more quickly to damage, says Antonio Ayala.


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